te_lanus: I doubt it wll. My pc's one side is open, and I have no problem.
I use(d) to do that with desktop PCs too. Sure I heard those warnings that the PC may overheat when the air is not flowing inside as intended (because you have the case open), but I never had such problems, in fact I am pretty sure my PCs ran cooler that way, including e.g. hard drives and such.
I don't quite believe in those "optimal airflow" arguments with desktops anyway as what you have inside (how many expansion cards, how many hard drives, how the cords go inside etc.) varies so much anyway, changing the various ways the air flows inside.
With laptops I can understand such concerns better as their innards don't vary, and they are made quite tight in order to save space.