chadjenofsky: Oh wow... I thought that the registry would have been somehow involved. Are all Gog games portable?
bevinator: Not all of them, but most of them. Basic registry things like installation paths are mostly removed, but some things remain. Several games won't work properly if you just port them. Dungeon Keeper 2, for example, uses the registry to track your campaign progress, so it can get into a weird state if your savegame doesn't match up to the campaign.
I recall also e.g. KKND2 having issues if the drive didn't match that where the game was originally installed.
(Well, KKND2 had issues even if it was installed correctly, like the infamous "mission failed"-bug...)