HOW TO GET THE BEST EXPERIENCE
1. This game has MIDI music, but there is a way to replace it with high quality recordings of original tapes. To do this, you must use SCUMMVM, the DOSBOX version sold here on GOG doesn't have the option to swap music files. To get this game working under SCUMMVM, do as described in this post:
https://www.gog.com/forum/i_have_no_mouth_and_i_must_scream/scummvm/post6
To get better music:
https://www.gog.com/forum/i_have_no_mouth_and_i_must_scream/enhanced_soundtrack_ingame_howto
2. This game is sort of like an "interactive movie", only done in adventure game fashion. The focus is on the story and the characters. DO NOT follow a guide verbatim like people are suggesting in other reviews as it's very distracting and makes the story less surprising and enjoyable. Try to beat every character's scenario by yourself - some times you can get things wrong and die, or get to a point where you can't progress further. Save often and think carefully. Look at everything and talk to everyone, this often triggers events. And watch out for actions that lower your "spiritual barometer" (pay attention to changes to music and your char's portrait).
3. Only use a guide when you get stuck, or, if you really want to make sure you will get the best ending, look at your character's portrait at the end of every chapter. If its background gets white, you did everything the way you should. If it does not, then you can use the guide to check and replay the "correct" way.
4. The best ending can be unachievable when you make mistakes early in the game, and there are at least a couple of points where you can get stuck with no way to progress. However, those quickly become obvious. If you will need to start over, you will have to restart only one chapter, and you can get through it quickly when you know what to do and skip all the dialogue. You won't need to replay the whole game, don't worry.
5. Enjoy one of the most atmospheric and memorable games in the world.
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